NSHD Approved Data Access Requests/Projects

The following table lists NSHD data access requests that have been approved.

Project IDYearPrincipal ApplicantTitleSummary
DAR2782018Dr Catherine CalvinAdult trajectories of inflammatory and cognitive change from mid to late life: A cross-cohort comparison studyThe principal aim of this study is to investigate whether within-individual change in the inflammatory biomarker C-reactive protein, in longitudinal follow-up, is predictive of later cognitive function, cognitive trajectories, and/or, dementia risk. Secondary aims are to test whether these associations are more present in particular age groups, and/or genetic risk groups (i.e. APOE e4 carriers). If the data allow, it may also be possible to test for causal inferences using CRP-relevant genotype data. CRP is a routinely collected measure in clinical practice, for screening and medication monitoring of a range of health outcomes in mid to late adulthood (i.e. cardiovascular disease, rheumatoid arthritis). If marked changes or sustained elevation in this biomarker over time, captured by existing routine testing, were shown to be helpful in risk prediction for cognitive-related outcomes?and indeed for specific age groups (alongside other risk factors)?this could be beneficial for preventative strategies targeted at reducing the population risk of dementia.
DAR2792018Henry HouldenSpontaneous intracranial haemorrhage (ICH) is the most devastating form of stroke with 40% mortality. Survivors have a high rate of progressive dementia. Therefore, causes and mechanisms of ICH are important contributing factors to dementia. Moreover, small vessel disease in ICH is likely to influence neurodegeneration generally; in particular insights into cerebral amyloid angiopathy (CAA), which causes ICH via rupture of amyloid-laden vessel-walls, will improve understanding of vascular mechanisms in Alzheimer’s disease.We hypothesise that novel genetic variants associated with ICH will reveal important information on overlapping causes of dementia, CAA and pathways involved in ICH. We collected clinical, imaging and DNA data on a UK cohort of 1,063 ICH patients, amongst them are 104 ICH families. We wish to investigate known genetic risk-factors for dementia and vascular disease, conduct a pilot genome-wide-association study for novel common variants combined with exome sequencing of familial ICH to identify overlapping highly penetrant.
DAR2802018Miharu NakanishiAssociation between psychosocial development in midlife and cognitive function in early old age.Recent research has emphasised risk reduction of cognitive impairment and dementia, with longitudinal studies investigating effects of social, mental, and physical lifestyle. The 3 major mechanisms for preventive strategies in dementia have concerned increasing cognitive reserve, reducing brain damage, and reducing brain inflammation. A major review by the Lancet Commission identified 9 potentially modifiable risk factors linked to dementia over the life course. However, relatively little is known about psychosocial factors in this context. Midlife wellbeing may mediate the impact of stress on the brain, and may compensate for long-term negative effects of early adversity during adjustment to ageing. The proposed analysis aims to investigate associations between wellbeing in midlife and cognitive function in later life using longitudinal data from NSHD.
DAR2812018Snehal Pinto PereiraThe relationship between time-varying adiposity and physical functioning in adulthood: examining effect-modification by time-varying physical inactivityAt the population level, effective treatment for obesity is not currently available, hence investigating whether (in)activity (a behaviour which is potentially more amenable to change than adiposity) could modify the adiposity burden on physical functioning is of relevance to health policy. While both adiposity and physical (in)activity are associated with poor functioning, it is unknown whether inactivity prevention could not only reduce the risk poor functioning by taking away its independent effect, but also by preventing the risk of poor functioning due to its interaction with adiposity. Therefore, we aimed to identify whether the association between adiposity in adulthood and mid-life physical functioning varied by physical inactivity. Of particular interest is whether risk of poor physical functioning associated with adiposity is reduced among those not classed as inactive.
DAR2822018Tom NorrisHow does growth in earlier life modify the relationship between adult BMI and cardio-metabolic outcomes & all-cause mortality?The majority of adults living in the United Kingdom (UK) are overweight or obese, which is a major public health concern as overweight/obese individuals are more likely (than normal weight individuals) to develop diseases representative of cardio-metabolic dysfunction (e.g. diabetes and hypertension). However, becoming overweight or obese does not confer the same long-term health prospects across individuals, with some people appearing more resilient than others to the negative outcomes associated with overweight/obesity. The goal of this project is therefore to understand why the adverse effects of obesity on markers of cardio-metabolic disease and all-cause mortality (e.g. glucose levels, blood pressure and blood lipid levels) are less severe in some people than in others.