Differences

This shows you the differences between two versions of the page.

Link to this comparison view

Both sides previous revision Previous revision
Next revision
Previous revision
mrepo:topics:biologicalsamplesanddna [15/05/2018 @ 11:41]
adammoore [Biological Samples, DNA and Structural Assessments]
mrepo:topics:biologicalsamplesanddna [15/05/2018 @ 16:28] (current)
adammoore
Line 3: Line 3:
 ---- ----
 ===Background=== ===Background===
 + ​Biological samples were collected for the first time at age 53; blood samples were used to measure indicators of risk factors for cardiovascular disease and nutritional markers.The samples also include a blood sample and a cheek swab from which DNA was extracted. A further sample was taken and stored for future cell line cultures. ​
 + 
  An intensive clinic data collection at age 60-64 years allowed the collection of new data on cardiac and vascular structure and function, bone and body composition,​ and biomarkers based on blood, urine and saliva samples, in addition to the functional measures, and health and lifestyle information that has previously been collected. ​  An intensive clinic data collection at age 60-64 years allowed the collection of new data on cardiac and vascular structure and function, bone and body composition,​ and biomarkers based on blood, urine and saliva samples, in addition to the functional measures, and health and lifestyle information that has previously been collected. ​
  
-LHA’s strategic plan 2008-13 identified the need for a NSHD DNA repository to support genetic studies of human health, disease and ageingthat make the best use of the available genetics resources, and the well characterised phenotypic resources. ​The director’s options appraisal in 2007 identified ​the need for (1) a highly automated and secure laboratory to manage the NSHD DNA samples, (2) MREC approval for a wide range of genetic studies ​with appropriate LHA governance, and (3a LHA genetics project manager to liaise with the repository ​and scientists wishing to use the resources.+LHA’s strategic plan 2008-13 identified the need for a NSHD DNA repository to support genetic studies of human health, disease and ageing that make the best use of the available genetics resources, and the well characterised phenotypic resources. ​LHA obtained approval from the Central Manchester Research Ethics Committee ​for genetic studies ​of lifelong healthdisease ​and ageing, with amendments to include Genome Wide Association Studies ​(GWAS), epigenomic studies ​and epigenome wide studies being subsequently approved 
  
-LHA obtained approval from the Central Manchester Research Ethics Committeefor genetic studies of lifelong health, disease and ageing, and for our proposed arrangements for the scientific and ethical review of requests for DNA resources and/or genotyping. ​ A substantial amendment to include Genome Wide Association Studies (GWAS) was approved in January 2009.  A further substantial amendment to include epigenomic studies and epigenome wide studies was approved in February 2012.  Reviews are undertaken by the NSHD Data Sharing committee and members ​of the NSHD Biological Samples Advisory Group+At 68-70 years non-fasting blood samples were collected at a home visit by research nurseswith a number ​of biomarkers being measured 
 +\\  
 +\\ 
  
   * [[mrepo:​topics:​biologicalsamples|Biological Samples]]   * [[mrepo:​topics:​biologicalsamples|Biological Samples]]