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mrepo:topics:biologicalsamplesanddna [15/05/2018 @ 11:28]
adammoore [Biological Samples, DNA and Structural Assessments]
mrepo:topics:biologicalsamplesanddna [15/05/2018 @ 16:28] (current)
adammoore
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 [[:​wiki:​Home|{{:​MRC-LHA-header-graphic.png}}]] [[:​wiki:​Home|{{:​MRC-LHA-header-graphic.png}}]]
 ==== Biological Samples, DNA and Structural Assessments ====  ==== Biological Samples, DNA and Structural Assessments ==== 
 +----
 +===Background===
 + ​Biological samples were collected for the first time at age 53; blood samples were used to measure indicators of risk factors for cardiovascular disease and nutritional markers.The samples also include a blood sample and a cheek swab from which DNA was extracted. A further sample was taken and stored for future cell line cultures. ​
 + 
 + An intensive clinic data collection at age 60-64 years allowed the collection of new data on cardiac and vascular structure and function, bone and body composition,​ and biomarkers based on blood, urine and saliva samples, in addition to the functional measures, and health and lifestyle information that has previously been collected. ​
 +
 +LHA’s strategic plan 2008-13 identified the need for a NSHD DNA repository to support genetic studies of human health, disease and ageing that make the best use of the available genetics resources, and the well characterised phenotypic resources. LHA obtained approval from the Central Manchester Research Ethics Committee for genetic studies of lifelong health, disease and ageing, with amendments to include Genome Wide Association Studies (GWAS), epigenomic studies and epigenome wide studies being subsequently approved.  ​
 +
 +At 68-70 years non-fasting blood samples were collected at a home visit by research nurses, with a number of biomarkers being measured. ​
 +\\ 
 +\\ 
 +
   * [[mrepo:​topics:​biologicalsamples|Biological Samples]]   * [[mrepo:​topics:​biologicalsamples|Biological Samples]]
   * [[mrepo:​topics:​DNA|DNA]]   * [[mrepo:​topics:​DNA|DNA]]
   * [[mrepo:​topics:​structuralassessments|Structural Assessments]]   * [[mrepo:​topics:​structuralassessments|Structural Assessments]]
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   * As these tests and assessments provide a huge number of independent and related measures, it has not been possible to select standard baskets. \\    * As these tests and assessments provide a huge number of independent and related measures, it has not been possible to select standard baskets. \\ 
-  * If you are interested in these data many variables are available on Skylark, so an appropriate keyword search [based on the measure(s) you are interested in] on [[skylark:​skylark|Skylark]] should give the results you need. \\ +  * If you are interested in these topics, ​many variables are available on Skylark, so an appropriate keyword search [based on the measure(s) you are interested in] on [[skylark:​skylark|Skylark]] should give the results you need. \\ 
   * For example, search for '​LDL'​ or '​cholesterol'​ for the relevant samples, or '​DXA'​ will give you all the DEXA measures collected at age 60-64.\\ ​   * For example, search for '​LDL'​ or '​cholesterol'​ for the relevant samples, or '​DXA'​ will give you all the DEXA measures collected at age 60-64.\\ ​
   * You can then [[mrclha.swiftinfo@ucl.ac.uk|email]] the [[skylark:​export|XML]] of your saved basket to us in support of your application.   * You can then [[mrclha.swiftinfo@ucl.ac.uk|email]] the [[skylark:​export|XML]] of your saved basket to us in support of your application.
 \\  \\ 
-**However, please note** that a large proportion of these data are __not__ available on Skylark due to their size or naturefor example DNA, activity data and other '​specialist'​ assessments and scans. Please [[mrclha.swiftinfo@ucl.ac.uk|contact us]] if your research may require access to the specialist datasets.+**However, please note** that a large proportion of these data are __not__ available on Skylark due to their size or naturefor example DNA, activity data and other '​specialist'​ assessments and scans. Please [[mrclha.swiftinfo@ucl.ac.uk|contact us]] if your research may require access to the specialist datasets.