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| - | Insight 46 is a neuroscience sub-study of the NSHD. Launched in 2015, Insight 46 recruited 502 study members selected at random from those who attended a clinical visit at 60–64 years and on whom relevant life course data are available. The study aims to investigate how life course factors and genetics influence the development of brain pathologies and impact on cognition, | + | Insight 46 is a neuroscience sub-study of the NSHD. Launched in 2015, Insight 46 recruited 502 study members selected at random from those who attended a clinical visit at 60–64 years and on whom relevant life course data are available. The study aims to investigate how life course factors and genetics influence the development of brain pathologies and impact on cognition, to provide insights into healthy brain ageing and the development of dementia. |
| For Insight 46, participants attended two clinic visits, two years apart. Each visit consists of a combination of brain imaging, biosampling and a clinical interview, including: | For Insight 46, participants attended two clinic visits, two years apart. Each visit consists of a combination of brain imaging, biosampling and a clinical interview, including: | ||